Rotterman Spinal Neuromechanics Lab

At Boston University

Our research aims to understand how spinal processing of proprioceptive information drives effective movement in healthy animals and how this goes awry in the context of neuropathy.

We use a multi-pronged approach to investigate these processes from synaptic biophysics to whole animal behavior.

Genetics and Cellular Neurobiology

Implementation of genetic rodent models to investigate inherited neuropathies such as Charcot-Marie-Tooth disease

In vivo electrophysiology

Use of sharp electrodes to conduct single cell recordings from motor and sensory neurons

Neural Network Analysis
Acute implantation of silicon multi-electrode arrays to recording extracellular neural activity in response to limb movement

Animal Behavior

Conducting behavioral assays, such as ladder walking, to interrogate sensorimotor control.

Our Approaches

Our Lab

The Rotterman Lab is part of the Department of Pharmacology, Physiology, and Biophysics of the Boston University School of Medicine, located in the South End neighborhood of Boston, MA. Through our multidisciplinary approach in this extraordinary city, we have the opportunity to push the boundaries of spinal neuromechanics, paving the way toward a better future for all.